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pentobarbital will reduce the extent or effect of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will lessen the extent or effect of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Females must not choose estradiol valerate/dienogest as th